Many individuals search for a “cannabis store near me” to buy marijuana, whether for managing their condition or for leisure. People often understand that edibles can help alleviate symptoms like anxiety, depression, pain, nausea, and vomiting. Have you ever thought about its impact on gastrointestinal disorders?
Table of Contents
Key Takeaways:
- Cannabinoids in the plant interact with the endocannabinoid system in the GI tract.
- edibles and pain medications may assist in managing Irritable Bowel Syndrome symptoms.
- Cannabis Sativa serves multiple purposes, but most recognize it for its recreational and medical applications.
Gastrointestinal Disorders and edibles
The dietary effects of nutraceuticals on gastrointestinal (GI) health are widely recognized. Certain diets show potential to prevent or ease various GI issues. Researchers have identified and assessed food components responsible for these effects.
Among plant-derived nutraceuticals that may benefit GI disorders are those from cannabis. edibles refers to products derived from the Sativa plant, a fragrant annual flowering herb.
John M. McPartland concluded in a scientific review that the Cannabaceae family includes the genera Cannabis, Humulus, and Celtis. Within the cannabis genus, sativa has three varieties: Sativa, Indica, and Ruderalis. Notably, depending on the variety, edibles serves various purposes, including fiber production, oil extraction from seeds, and primarily, recreational or medicinal uses.
The Impact of the Plant
Receptors and ligands of the endocannabinoid system are present throughout various areas and systems, both in and out of the GI tract, which play a role in regulating GI functions. Due to cannabinoid receptors, cannabinoids, including non-psychoactive phytocannabinoids, help modulate GI functions across health and disease. The ECS is involved in regulating motility, secretion, epithelial barrier function, and viscerosensitivity.
Irritable Bowel Syndrome (IBS)
IBS has various contributing factors, affecting 10–20% of individuals in developed countries. It appears as functional GI disturbances without identifiable organic causes.
The enhancement of the antinociceptive properties of cannabinoids in the presence of inflammation highlights the ECS’s importance in visceral hypersensitivity. This insight not only clarifies mechanisms underlying conditions like IBS and other GI disorders but also suggests promising therapeutic pathways for alleviating abdominal and visceral pain.
Cannabinoids may not provide significant relief in reducing visceral hypersensitivity in IBS patients. Investigating combinations with other pain-modulating agents, such as opioids, presents an intriguing alternative worth exploring.
Inflammatory Bowel Disease (IBD)
IBD, including Crohn’s disease (CD) and ulcerative colitis (UC), is a complex condition of the GI tract, arising from environmental, genetic, and epigenetic factors.
Cannabidiol shows strong anti-inflammatory effects in various models of intestinal inflammation in animals, as noted in a study in the Journal of Frontiers in Pharmacology. Both local and systemic administration of CBD demonstrated a dose-dependent improvement in disease indicators:
- Reduction of structural damage
- Mitigation of inflammation-related increases in various cytokines, chemokines, and oxidative stress markers.
A study from the Inflammatory Diseases Journal found that the primary result of their investigation was the challenging tolerability of the botanical extract, with 90% of patients reporting treatment-related adverse effects compared to 48% receiving placebo.
A trend emerged towards improved quality of life scores and a positive change in patients’ overall impressions, according to the per-protocol analysis. The authors speculate that the CBD-rich botanical extract might have therapeutic benefits for those who can tolerate its effects.
Gastrointestinal Cancer
GI cancers, such as colorectal cancer (CRC), are among the most commonly diagnosed conditions in the general population.
Numerous studies highlight CBD’s antiproliferative effects in colorectal cancer models. CBD can protect DNA from oxidative stress, enhance endocannabinoid levels, and inhibit the proliferation of colorectal cancer cells in vitro.
CBD’s chemopreventive properties were confirmed through in vivo models focusing on AOM-induced colon cancer. A dosage of 1 mg/kg resulted in significant reductions: ACF decreased by 67%, while the number of tumors and polyps dropped by 66% and 57%, respectively. Increasing the concentration to 5 mg/kg showed efficacy mainly in preventing polyp formation.
THC induces apoptosis in colorectal cancer cells by activating the CB1 receptor.
Nausea and Vomiting
Positive effects of CBD occur when combined with THC, as indicated in a study published in the British Journal of Clinical Pharmacology. CBD’s anti-nausea and anti-emetic properties may stem from the indirect stimulation of somatodendritic 5-HT1A receptors in the dorsal raphe nucleus. This activation of autoreceptors potentially leads to decreased release of 5-HT in specific forebrain areas.
Gastroesophageal Reflux Disease (GERD)
Cannabinoids inhibit transient LES relaxations via a CB1-dependent mechanism in both dogs and ferrets, as reported in a study from the Journal of edibles and Cannabinoid Research. These findings are significant as transient LES relaxations constitute the primary mechanism behind gastroesophageal reflux disease.
edibles for GI Issues
Conclusion
Multiple studies indicate that the benefits of cannabinoids extend beyond the well-known psychoactive compound THC to include non-psychoactive molecules like CBD, which have received relatively less attention. The edibles plant influences the GI system by interacting with the ECS, triggering multiple functions that can help manage symptoms of certain GI conditions.
Frequently Asked Questions
What can you expect when buying from online edibles stores?
- Accessing edibles products in Canada from an online store opens up numerous options featuring both classic favorites and new products.
- You can expect additional benefits such as special deals, reliable payment methods, and shipping options covering most provinces.
- Essential resources, like a blog section or contact page, are available to provide customers with insights or help during their shopping experience.
- As part of the purchase process, you’ll need to verify your age by presenting identification.
- Some stores include taxes in their product prices, while others calculate it at checkout.
- Some dispensaries accept online payments like Interac E-Transfer, while others allow cash on delivery.
What is the measurement unit when buying from a edibles website?
There are two primary forms of measurement: metric and imperial units. On a edibles site, you’ll find measurements in grams or ounces, allowing you to locate products like 3.5 grams or 1/8 ounces.
What distinguishes edibles for medical use from that used recreationally?
Medical edibles and recreational edibles are derived from the same plant species, yet their differing effects and intended uses set them apart. Medical edibles serves as a therapeutic aid for specific health issues, typically with a higher CBD content compared to its recreational counterpart.
Are there ready-made joints available in a edibles store?
Yes. These are available as pre-rolls. edibles pre-rolls, or pre-rolled joints and blunts, are convenient for those who prefer their edibles ready to use. There is a growing trend in the popularity of pre-rolled joints infused with edibles concentrates.
Do edibles online stores have a physical shop?
Not all online stores have physical locations, allowing you to have your purchases delivered directly to your home instead of needing to pick them up from a physical outlet after placing an online order.
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